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2 678 846

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IPC

C07C275/68(2006-01-01)

A61K31/175(2006-01-01)

A61P35/00(2006-01-01)

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Application

2018140004, 2018-11-12

(24)

Start date

2018-11-12

(22)

Actual filing date

2018-11-12

(45)

Published

2019-02-04

(72)

Inventor

Stukov Aleksandr NikolaevichEsikov Kirill AleksandrovichUsmanova Liliya MaratovnaKonkov Sergej AnatolevichSemiglazova Tatyana YurevnaFilatova Larisa ValentinovnaBespalov Vladimir GrigorevichTochilnikov Grigorij ViktorovichVasileva Olesya AleksandrovnaKireeva Galina SergeevnaSemenov Aleksandr LeonidovichSenchik Konstantin YurevichKozyavin Nikita AleksandrovichVershinina Sofiya FatkhutdinovnaPoltoratskij Artem NikolaevichKonstantinov Leonid VladimirovichTyndyk Margarita LeonidovnaPanchenko Andrej VladimirovichMajdin Mikhail AleksandrovichYurova Mariya NikolaevnaEgormin Petr AndreevichPlakhov Evgenij AleksandrovichAnisimov Vladimir Nikolaevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Meditsinskij Issledovatelskij Tsentr Onkologii Imeni N.N. Petrova" Ministerstva Zdravookhraneniya Rossijskoj Federatsii

METHOD OF SYNTHESIS 2-[3-(2-CHLORETHYL)-3-NITROSOUREIDO]-1,3-PROPANE-DIOL OWNED WITH ANTITUMOR ACTIVITY Russian patent published in 2019 - IPC C07C275/68 A61K31/175 A61P35/00

Abstract RU 2678846 C1

FIELD: chemistry.

SUBSTANCE: invention relates to the synthesis of 2-[3-(2-chloroethyl)-nitrosoureido]-1,3-propanediol with antitumor activity. Method consists in the interaction of 2-chloroethyl isocyanate with 2-amino-1,3-propane-diolol in the presence of a mixture of acetonitrile-methanol in a ratio of 2:1 with receiving an intermediate product of 2-[3-(2-chloroethyl)ureido]-1,3-propane diol, that is nitrosated in the presence of a 50 % aqueous solution of formic acid according to the following scheme:

EFFECT: method allows to expand the arsenal of means for the synthesis of 2-[3-(2-chloroethyl)-nitrosoureido]-1,3-propanediol and to increase the degree of conversion and increase the purity of the intermediate and final products of the synthesis.

1 cl, 7 dwg, 8 tbl, 7 ex

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RU 2 678 846 C1

Authors

Stukov Aleksandr Nikolaevich

Esikov Kirill Aleksandrovich

Usmanova Liliya Maratovna

Konkov Sergej Anatolevich

Semiglazova Tatyana Yurevna

Filatova Larisa Valentinovna

Bespalov Vladimir Grigorevich

Tochilnikov Grigorij Viktorovich

Vasileva Olesya Aleksandrovna

Kireeva Galina Sergeevna

Semenov Aleksandr Leonidovich

Senchik Konstantin Yurevich

Kozyavin Nikita Aleksandrovich

Vershinina Sofiya Fatkhutdinovna

Poltoratskij Artem Nikolaevich

Konstantinov Leonid Vladimirovich

Tyndyk Margarita Leonidovna

Panchenko Andrej Vladimirovich

Majdin Mikhail Aleksandrovich

Yurova Mariya Nikolaevna

Egormin Petr Andreevich

Plakhov Evgenij Aleksandrovich

Anisimov Vladimir Nikolaevich

Dates

2019-02-04—Published

2018-11-12—Filed