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2 752 083

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IPC

A61K31/175(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2020133754, 2020-10-13

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Start date

2020-10-13

(22)

Actual filing date

2020-10-13

(45)

Published

2021-07-22

(72)

Inventor

Stukov Aleksandr NikolaevichKharitonova Natalya NikolaevnaKulikov Aleksej NikolaevichZmitrichenko Yuliya GennadevnaSemiglazova Tatyana YurevnaFilatova Larisa ValentinovnaLatipova Dilorom KhamidovnaVershinina Sofiya FatkhutdinovnaBespalov Vladimir GrigorevichVasileva Olesya AleksandrovnaKireeva Galina SergeevnaSemenov Aleksandr LeonidovichSenchik Konstantin YurevichTochilnikov Grigorij ViktorovichBogodyazh Evgenij GrigorevichMurazov Yaroslav GennadevichTyndyk Margarita LeonidovnaPoltoratskij Artem NikolaevichYurova Mariya NikolaevnaVasileva Irina NikolaevnaIvantsov Aleksandr OlegovichAnisimov Vladimir Nikolaevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Meditsinskij Issledovatelskij Tsentr Onkologii Imeni N.N. Petrova" Ministerstva Zdravookhraneniya Rossijskoj Federatsii

APPLICATION OF COMPOUND 2-[3-(2-CHLOROETHYL)-3-NITROSOUREIDO]-1.3-PROPANEDIOL FOR TREATMENT OF EHRLICH CARCINOMA, SARCOMA 37, LIO-1 LYMPHOSARCOMA, MELANOMA B16, TRANSPLANTED INTO LOWER EYELID OF MICE IN EXPERIMENT Russian patent published in 2021 - IPC A61K31/175 A61P35/00

Abstract RU 2752083 C1

FIELD: medicine.

SUBSTANCE: invention relates to the use of the compound 2-[3-(2-chloroethyl)-3-nitrosoureido]–1.3-propanediol for the treatment of Ehrlich carcinoma, sarcoma 37, lymphosarcoma LIO-1, melanoma B16, transplanted into the lower eyelid of mice in an experiment at a dose of 15 or 20 mg/kg once intraperitoneally. The claimed use of 2-[3-(2-chloroethyl)-3-nitrosoureido]-1.3-propanediol can achieve 100% inhibition of the growth of eyelid tumors and increase the median life expectancy of animals, respectively, by 84%, > 154%, > 150% and 67%. In mice with sarcoma 37 and LIO-1 lymphosarcoma transplanted under the skin of the lower eyelid, a single administration of 2-[3-(2-chloroethyl)-3-nitrosoureido]-1.3-propanediol at a dose of 20 mg/kg resulted in complete recovery of 89% and 67% of the animals, respectively.

EFFECT: extension of the range of experimental pharmaceuticals.

1 cl, 16 dwg, 8 tbl, 4 ex

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RU 2 752 083 C1

Authors

Stukov Aleksandr Nikolaevich

Kharitonova Natalya Nikolaevna

Kulikov Aleksej Nikolaevich

Zmitrichenko Yuliya Gennadevna

Semiglazova Tatyana Yurevna

Filatova Larisa Valentinovna

Latipova Dilorom Khamidovna

Vershinina Sofiya Fatkhutdinovna

Bespalov Vladimir Grigorevich

Vasileva Olesya Aleksandrovna

Kireeva Galina Sergeevna

Semenov Aleksandr Leonidovich

Senchik Konstantin Yurevich

Tochilnikov Grigorij Viktorovich

Bogodyazh Evgenij Grigorevich

Murazov Yaroslav Gennadevich

Tyndyk Margarita Leonidovna

Poltoratskij Artem Nikolaevich

Yurova Mariya Nikolaevna

Vasileva Irina Nikolaevna

Ivantsov Aleksandr Olegovich

Anisimov Vladimir Nikolaevich

Dates

2021-07-22—Published

2020-10-13—Filed