FIELD: organic chemistry, pharmacology, pharmacy. SUBSTANCE: invention relates to novel derivatives of 7-[3-[4-(6- fluorobenzo[d]isoxazol-3-yl)piperidine-1-yl]-propoxy]-chromen-4-one of the formula (I)
where R means hydrogen atom, CHO, CH2OR2 or COOH; R1 means alkyl with from 1 to 4 carbon atoms under condition that one of substituent R and R1 is hydrogen atom and their pharmaceutically acceptable salts designated for use in treatment of patients with psychosis and schizophrenia. Invention relates to also a method of synthesis of these compounds, pharmaceutical composition based on thereof and method of inhibition of D2--, 5-HT2a- and H1-receptors in treatment of patients with psychosis and schizophrenia. EFFECT: synthesis of new compounds used in medicine as drugs, valuable medicinal properties. 7 cl, 3 tbl, 12 ex
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METHOD FOR PREPARING 3-{2-[4-(6-FLUOROBENZO[D]ISOXAZOLE-3-YL)PIPERIDINE-1-YL]ETHYL}-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDINE-4-ONE, INTERMEDIATE DERIVATIVES FOR ITS PREPARING AND METHOD FOR PREPARING INTERMEDIATE DERIVATIVE |
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