5-HT- AND D-RECEPTOR DOUBLE MODULATORS Russian patent published in 2013 - IPC C07D413/04 C07D413/14 A61K31/454 A61K31/497 A61K31/501 A61K31/506 A61P25/18 A61P25/24 A61P25/30

Abstract RU 2480466 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of general formula

, wherein X represents a halogen atom or C_1-6-alkyl; and has the value of 0, 1, 2 or 3; R¹ represents H; R² represents or ; R³ represents C_1-6-alkyl, C_3-10-cycloalkyl, phenyl, 6-member heterocycloalkyl representing tetrahydropyranyl, or 5-10-member heteroaryl specified in pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, benzo[1,3]dioxolyl and 2,3-dihydrobenzo[1,4]dioxynyl; which be substituted and contains one to five substitutes specified in the patent claim. The invention also refers to pharmaceutical compositions possessing high affinity to dopamine D₃ receptor and serotonin 5-HT_2A receptor containing said compounds, and the use thereof in preparing drugs.

EFFECT: preparing the compounds of formula (I) possessing high affinity to dopamine D₃ receptor and serotonine 5-HT_2A receptor.

15 cl, 4 dwg, 5 tbl, 78 ex

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RU 2 480 466 C2

Authors

Gobbi Luka

Eshke Georg

Rosh Oliv'E

Rodrigez Sarmiento Roza Marija

Stjuard Lusinda

Dates

2013-04-27—Published

2008-07-17—Filed