NOVEL DERIVATIVES OF 2,4-DIOXOPYRROLIDINE AND 2,4-DIOXOTETRA-HYDROFURAN AND MEDICINAL AGENTS CONTAINING THEIR AS ACTIVE COMPONENT Russian patent published in 2002 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel 1-(biphenyl-4-yl)-methyl-1H-1,2,4-triazole compounds and 1-(biphenyl-4-yl)-methyl-4H-1,2,4-triazole compounds being each compound has (2,4-dioxopyrrol-idine-5-ylidene)-methyl or (2,4-dioxotetrahydrofuran-5-ylidene)-methyl as a substituent at 2'-position and their salts also. Compounds show the strong antagonism to angiotensin-II receptors and antihypotensive effect and they can be used as therapeutic agent in disease of circulatory system, for example, in hypertension or for treatment of patients with cardiac failure. EFFECT: new compounds indicated above, valuable medicinal properties. 9 cl, 1 tbl, 2 sch, 4 ex