METHOD OF DIFFERENTIATED PREDICTION OF RENAL DISEASES Russian patent published in 2002 - IPC

FIELD: medicine, nephrology. SUBSTANCE: the method deals with testing urinary proteins by automatically controlled electrophoresis in a gradient 8-25%-polyacrylamide gel with dodecyl sodium sulfate detergent. Moreover, protein fractions are studied within 10-330 kDa range. At combining protein fractions of 25-27 kDa mol. weight-α₁-microglobulin, α₁-acid glycoproteide and 58-75 kDa-prealbumin, albumin, postalbumin the standard is diagnosed. At determining protein fractions of 58-75 kDa mol. weight-prealbumin, albumin, postalbumin, 76-160 kDa-transferrin, monomer THP, haptoglobin, dimeric A1, immunoglobulans G and 161-330 kDa- immunoglobulins' fraction the glomerulopathies are diagnosed. At combining protein fractions of 10-24 kDa mol. weight - γ trace protein, β2-microglobulin, ribonuclease, lysozyme, monomeric hemoglobin, retinolbinding protein, 58-75 kDa - prealbumin, albumin, postalbumin, 76-160 kDa-transferrin, monomer THP, haptoglobin, dimeric A1, immunoglobulin G and 161-330 kDaimmunoglobulins' fraction - a combinative defects of glomerules and canaliculi are diagnosed, that is glomerulonephritis with tubulointerstitial component, at determining uroproteins of 10-24 kDa mol. weight - γ trace protein, β2-microglobulin, ribonuclease, lysozyme, monomeric hemoglobin, retinolbinding protein, 25-27 kDa-α₁-microglobulin, α₁-acid glycoproteide, 58-75 kDa-prealbumin, albumin, postalbumin, 76-160 kDa-transferrin, monomer THP, haptoglobulin, dimeric A1, immunoglobulin G the tubulointerstitial nephritis and tubulopathies are diagnosed. EFFECT: higher accuracy of differentiated diagnostics of renal diseases. 3 tbl