22-THIAVITAMIN D DERIVATIVES, METHOD OF PREPARATION THEREOF, METHOD FOR PREPARATION OF COMPOUNDS, AND COMPOUNDS Russian patent published in 1999 - IPC

FIELD: biologically active compounds. SUBSTANCE: new 22-thiavitamin D₃ derivatives with general formula I: (I) wherein R₁ is C₁-C₁₀-alkyl optionally substituted by hydroxyl group, R₂ hydrogen atom or hydroxyl, and R₃ hydroxyl. Vitamins show wide spectrum of physiologic activities. Intermediate products and synthetic procedures are also described. Derivatives of vitamins substituted by sulfur atom in position 22 exhibit strong inhibiting effect with respect to proliferation of keratinocytes. EFFECT: extended physiologic activities. 36 cl, 5 dwg, 91 ex