METHOD OF PREPARING ADAMANTYLPHENYLCARBOXYLIC ACIDS Russian patent published in 2002 - IPC

FIELD: organic synthesis. SUBSTANCE: adamantylphenylcarboxylic acids widely usable for synthesis of medicaments are prepared by oxidizing corresponding alkylphenyladamantanes with air oxygen in presence of variable valence metal-based catalyst and sodium bromide as initiator. Reaction is carried out in solvent: acetic acid/dioxane mixture at volume ratio (10-20): 1. Weight ratio of catalyst + initiator to alkylphenyladamantane is 1: (6.9-20). Preferable temperature is 75-100 C. As catalyst, cobalt acetate/manganese acetate mixture initiated by sodium bromide can be used. Weight ratio of initial hydrocarbon to acetic acid varies between 1:15 and 1:30. EFFECT: enhanced process efficiency due to increased yield if desired products, reduced charge of catalyst, and reduced reaction time. 2 cl, 3 ex