DERIVATIVES OF NITROMETHYLTHIOBENZENE, METHOD OF THEIR SYNTHESIS (VERSIONS) AND PHARMACEUTICAL COMPOSITION Russian patent published in 2002 - IPC

FIELD: organic chemistry, biochemistry, chemical technology, medicine, pharmacy. SUBSTANCE: invention relates to novel derivatives of nitromethylthiobenzene of the general formula 1 where P means the radical (I) , (II) or (III) . Invention describes methods of synthesis of these compounds and their using as medicinal agents. These compounds inhibit activity of enzyme aldosoreductase and can be used for treatment or prophylaxis of peripheral and autonomic neurological complications associated with diabetes, renal and ophthalmic damages, for example, cataract and retinopathy. EFFECT: new compounds indicated above, improved method of synthesis, valuable medicinal properties. 20 cl, 1 tbl