FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention relates to compounds of formula I and to pharmaceutically acceptable salts thereof, wherein R1, Ra, Rb and Z are as defined in claim 1. Invention also relates to a pharmaceutical composition containing same and to use thereof in the prevention and treatment of diseases associated with increased expression of IRAK, such as inflammatory diseases, autoimmune diseases, cancer, multiple sclerosis. 
.
EFFECT: pyridazinone-amide derivatives are disclosed.
12 cl, 18 ex
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