SUBSTITUTED PIPERIDINE-2,6-DIONES AND METHODS OF THEIR SYNTHESIS Russian patent published in 2002 - IPC

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to novel substituted piperidine-2,6-diones of the formula (I): where Z means -C(R¹R²)-CH₂ or -C(R¹)-CH-; R¹ means phthalimide when Z means -C(R¹R²)-CH₂- or phthalimide radical substituted once or twice with hydroxy-group, methoxy-group or amino-group when Z means -C(R¹)= CH-; R² means hydrogen atom or C_1-6-alkyl group; R³ means hydrogen atom, C_1-6-alkyl group or aromatic ring system, and R⁴ means C_1-6-alkyl or aromatic ring. Compounds of the formula (I) show inhibitory effect on release of TNF-α (tumor necrosis alpha-factor) and on an antigen-induced synthesis of interleukin-2. Compounds of the formula (I) can be synthesized by condensation of phthalic anhydride with substituted glutamic acid followed by cyclization of synthesized product and its conversion to amide. Another method of synthesis of compound of the formula (I) involves condensation of phthalic anhydride with substituted 3-aminoglutaconimide or 5-substituted 3-aminoglutarimide. EFFECT: new compounds indicated above, valuable medicinal properties, improved methods of synthesis. 5 cl, 1 tbl, 4 ex