2,6-DIOXOPIPERIDINE, METHOD FOR REDUCTION OF UNDESIRABLE LEVELS OF TNF-ALPHA IN MAMMAL, PHARMACEUTICAL COMPOSITION Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, oncology, pharmacy. SUBSTANCE: invention describes 2,6-dioxopiperidine consisting of: (a) compound of the formula (I) α where one of X and Y means C=O and another of X and Y means C=O or ; one of CH₂ means R¹,R²,R³,R⁴ and others are hydrogen atom; -NHR⁵ means hydrogen atom, R⁵-alkyl, CO-C_1-8; R⁷-CH(R¹⁰)NR⁸R⁹ means R⁶-alkyl; C_1-8 means R⁷; n = 0; each of (C_nH_2n) and R⁸ means independently each of other hydrogen atom, R⁹-alkyl; C_1-8 means hydrogen atom and: (b) addition salt of indicated compounds that comprise nitrogen atom that is able for protonation. Invention describes also method for reduction of undesirable levels of TNF-R¹⁰ in mammal by administration of effective dose of indicated compound and pharmaceutical composition used for reduction of undesirable levels of TNF-α in mammal comprising indicated compound in the dose sufficient for reduction of levels of TNF-α in regime administration as a single or multiple doses in combination with a carrier. Compounds reduces levels of TNF-α in mammal. EFFECT: improved method for reduction of factor level. 4 cl, 1 tbl, 26 ex _