FIELD: medicine, vaccine prophylaxis. SUBSTANCE: it is suggested to use capsule fraction 1 antigen F1 Y.pestis and, additionally, B-antigen isolated from cellular biomass of Y. Pseudotuberculosis. B-antigen is a large-molecular antigenic complex including polysaccharide, protein and lipid components. Primary immunization by said preparation could induce the development of pronounced specific insusceptibility to plague infection in white mice, guinea pigs, hamadryas baboons and is characterized by moderate post-vaccination reaction in experimental animals. EFFECT: higher efficiency of vaccine prophylaxis of plague. 1 cl, 3 ex, 5 tbl
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