METHOD OF SYNTHESIS OF ANTAGONISTS OF NMDA (N-METHYL-D-ASPARTATE) Russian patent published in 2002 - IPC

FIELD: organic chemistry, derivatives of amino acids. SUBSTANCE: invention relates to a method of synthesis of compound of the formula (I) where R¹ and R² mean phenyl or 4-fluorophenyl; R³ means hydrogen atom, alkyl or methoxycarbonyl; R⁴ means hydrogen atom or methyl. Synthesis is performed by interaction o compound of the formula (II) with compound of the formula (III) where R⁵, R⁶, R⁷, R⁹, R¹⁰ mean alkyl to yield compound of the formula (IV) and the following removal of a protective group and the following optional formation of a pharmaceutically acceptable salt. An advantage of the proposed method involves the significantly increased yield and method provides preparing the end product of good purity. EFFECT: improved method of synthesis, increased yield and quality. 16 l, 3 ex