DERIVATIVES OF THIENO[2,3-D]PYRIMIDINE-2,4-(1H,3H)-DIANE, PHARMACEUTICAL COMPOSITION, METHOD FOR ITS PREPARING, METHOD FOR IMMUNOSUPPRESSION AND METHOD FOR TREATMENT OR REDUCING RISK OF RESPIRATORY WAY OBSTRUCTION Russian patent published in 2004 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to new derivatives of then[2,3-d]- pyrimidine-2,4-(1H,3H)-done of the general formula (I) or their pharmaceutically acceptable salts eliciting immunosuppressive activity. Invention relates also to pharmaceutical composition, method for its preparing, method for immunosuppression and method for treatment or reducing risk of obstruction of respiratory ways. In compounds of the general formula (I) R represents -C(O)-Ar¹, -C(R⁴)(R⁵)Ar¹ or Ar² wherein Ar¹ represents naphthyl, quaintly, isoquinolyl or benzofuranyl; or Ar¹ represents phenyl optionally substituted with one or some substituents taken among: C_1-4-alkyl, C_1-4-alkoxy-group, halogen atom, trifluoromethyl, amino-, nitro-, cyano-, trifluoromethoxy-, phenoxy-group, -CH₂N(R⁶)₂, -NHSO₂CF₃, C_1-4-alkylsulfonylamino-group, -NHC(O)R^6a, CO₂R⁷ or -C(O)NR⁸R^8a; R⁴ represents hydrogen atom; R⁵ represents hydrogen atom or OH; each R⁶ and R⁷ represents hydrogen atom or C_1-4- alkyl; R^6a represents hydrogen atom, C_1-6-alkyl, aryl or aryl-C_1-4-alkyl wherein alkyl group or aryl moiety in arylalkyl group represents phenyl or pyridyl being each of them can be substituted optionally with one or some substituents; R⁸ and R^8a each represents independently hydrogen atom, C_1-4-alkyl, phenyl or pyridyl; Ar² represents acenaphthenyl, indanyl, iminodihydrobenzofuranyl or fluorenyl and each of them can be substituted optionally with one or some substituents; R¹ and R² represent independently C_1-6-alkyl, C_3-6-alkenyl, CH₂C_3-5-cycloalkyl or C_3-6-cycloalkyl; R³ represents hydrogen atom, X-R⁹ or X-Ar³ wherein X represents S(O)_n, C(O)NR¹⁰, C(O)O, NH(CO)NR¹⁰, NH(CO)O or SO₂NR¹⁰; n = 0, 1 or 2; X, R⁹ and R¹⁰ are given in the invention claim; Ar³ represents phenyl, pyridyl or pyridine N-oxide and each of them can be substituted optionally with one or some substituents taken among: OH, NO₂, NH₂, NHSO₂CF₃, C_1-4-alkoxy-group, bis-C_1-4-alkanesulfonylamino-group, C_1-4- alkylcarbonylamino-group or C_1-4-alkoxycarbonylamino-group. EFFECT: improved preparing and treatment methods, valuable medicinal properties of compounds. 17 cl, 95 ex _