SUBSTITUTED 2-NAPHTHOYLGUANIDINES AND MEDICINAL AGENT BASED ON THEREOF Russian patent published in 2002 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I) where R1, R3-R8 mean XYaWZ or X'YaWZ' where X is O; Y means alkylene with 1-4 CH₂ groups; a = 0; W is CH₂ or if W does not follow directly after heteroatom of XYa group then it means O also; Z is - C(=O)R15 or if W does not mean O then it means NR16R17 also; R15 is ; R16 and R17 mean hydrogen atom or alkyl; or R(16) and R(17) mean in common 4 or 5 methylene groups from that one CH₂ group can be substituted with oxygen atom or N-(p-chlorophenyl); X' is -C(=O)NR(30); Z' means C(= O)R15, N-containing heterocycle with 1-5 C-atoms being N-containing heterocycle is bound through C-atom; other R1, R3-R8 that do not fall within for said values mean independently each of other VpQqU where V is O; p = 0 or 1; U is hydrogen atom, alkyl being one of substitutes R4-R8 does not mean hydrogen atom. The above indicated compounds show an inhibitory activity with respect to Na⁺/H⁺-exchange and therefore they can be used as an active substance in a drug used for treatment of different diseases associated with a property of said compounds. EFFECT: valuable medicinal properties of compounds. 10 cl, 1 tbl, 8 ex