CINNAMIC ACID SUBSTITUTED GUANIDIDES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION Russian patent published in 2002 - IPC

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention describes cinnamic acid substituted guanidides of the formula (1) where R(3) means -X_a-У_б-L_n-U where X means O, S; "a" = 0 or 1; Y means alkylene with 1, 2, 3, 4, 5, 6, 7 or 8 C-atoms; T where T means alkylene with 1, 2, 3, 4, 5, 6, 7 or 8 C-atoms in alkylene moiety; T means phenylene; "n" = 0; U means NR(24), R(25) or pyridyl being R(24) and R(25) means alkyl with 1, 2, 3, 4, 5, 6, 7 or 8C-atoms; R(1), R(2), R(4) and R(5) mean H, F, Cl, Br, J, CN, -O_p-(CH₂)_s-C_qF_2q+1 where "p" = 0; "q" = 1, 2, 3, 4, 5, 6, 7 or 8; "s" = 0; R(6) and R(7) mean independently each of other hydrogen atom, F, Cl, Br, J, alkyl with 1, 2, 3, 4, 5, 6, 7 or 8 C-atoms, and their pharmaceutically acceptable salts also. Novel compounds are inhibitors of cellular sodium-protonic exchange. Invention describes also a method of synthesis of compounds of the formula (1) and a pharmaceutical composition eliciting an inhibitory activity with respect to Na⁺/H⁺-exchange and comprising a compound of the formula (1) as an active substance. EFFECT: improved method of synthesis, valuable medicinal properties. 6 cl, 1 tbl, 12 ex