ORTHO-SUBSTITUTED BENZOYLGUANIDINES AND MEDICINAL AGENT BASED ON THEREOF Russian patent published in 2002 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to ortho-substituted benzoylguanidines of the formula (1) where R(1) means R(13)-So_m; m = 2; R(13) means alkyl, one of substitutes R(2) and R(3) means hydrogen atom and another means CHR(30)R(31) where R(30) means -(CH₂)g-(CHOH)h--(CH₂)I(CHOH)k-R(32) where R(32) means hydrogen atom or methyl group; g, h, I = 0; k = 1; R(2) and R(3) mean -C(OH)R(33)R(34); R(31), R(33) and R(34) mean hydrogen atom or alkyl; R(4) means alkyl, alkoxy-group, F, Cl, Br, J. These compounds show inhibitory activity with respect to Na⁺/H⁺-exchange and owing to said property they can be used as medicinal agent against different diseases. EFFECT: valuable medicinal properties of compounds. 10 cl, 3 ex