FIELD: biotechnology. SUBSTANCE: in order to obtain bificine probiotic preparation one should use the biomass of the following strains: Bifidobacterium longum B-12, Lactobacillus plantarum P-19, Enterococcus faecium E- 18, Bacillus subtilis B-26 obtained from the healthy early- aged calves and efficient as prophylactic and curative preparation at diarrheal diseases in calves. Said probiotic preparation is of wide antimicrobial action spectrum against conventionally-pathogenic and pathogenic microorganisms, synthesizes biologically active substances and increases nonspecific body resistance in calves. EFFECT: higher efficiency.
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