AZACYTIDINE ANALOGUES AND USE THEREOF Russian patent published in 2013 - IPC C07H19/06 A61K31/7072 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to new compounds of formula (I):

, wherein R represents H, R₅C(O), R₅CH₂OC(O) or R₅CH₂NHC (O); R₁ represents or wherein an intersecting dash line shows a bond formed by attaching R₁ to a molecule of formula (I); R₂ and R₃ independently represent OH or provided R₂ and R₃ are not OH simultaneously; R₄ represents H; R₅ has a general formula: CH₃-(CH₂)_n-(CH=CH-CH₂)_m-CH=CH-(CH₂)_k-; k represents an integer 0 to 7; m represents an integer 0 to 2; and n represents an integer 0 to 10, or their pharmaceutically acceptable salts thereof. These compounds possess anticancer activity.

EFFECT: invention refers to a pharmaceutical compositions of these compounds and to the use of them for preparing a drug for cancer diseases.

15 cl, 4 tbl, 11 ex, 1 dwg