TECHNIQUES AND COMPOSITIONS USED TO INHIBIT αβ-CAUSED ANGIOGENESIS Russian patent published in 2002 - IPC

FIELD: pharmacology. SUBSTANCE: tissue angiogenesis is inhibited using vitronectin α_vβ₅ antagonists. α_vβ₅.-Mediated angiogenesis is correlated with effect of cytokines, including endothelial growth factor, transforming growth factor-α_vβ₅-, and epidermal growth factor. Inhibition of α-mediated angiogenesis is especially preferred in cases of endothelial eye diseases with revascularization, tumor growth, and inflammatory diseases where inhibition is realized by the aid of therapeutic compositions integrin α_vβ₅- antagonists. EFFECT: extended choice of drugs against angiogenesis-caused diseases. 36 cl, 21 dwg, 2 tbl