METHODS FOR TREATMENT OF TUMORS AND METASTASIS USING COMBINATION OF ANTI-ANGIOGENIC THERAPY AND IMMUNOTHERAPY Russian patent published in 2004 - IPC

Abstract RU 2236251 C2

FIELD: medicine, oncology.

SUBSTANCE: invention relates to methods for treatment of tumors and metastasis using the combination of an anti-angiogenic therapy and immunotherapy. Invention involves a method for treatment of neuroectodermal and epithelial tumor in patient, therapeutic combination and set for treatment of tumor cell using an agent inhibiting angiogenesis and representing antagonist of α_vβ₃ and anti-tumor immunotherapeutic agent comprising cytokine component of cell-effector and component of immunoglobulin Ig-polypeptide directed to the tumor-associated antigen and comprising variable region that is bound with the tumor-associated target-antigen. The advantage of invention involves application of an anti-angiogenic therapy for treatment of tumors.

EFFECT: enhanced effectiveness and valuable medicinal properties of methods.

26 cl, 4 dwg, 1 tbl, 10 ex

Similar patents RU2236251C2

Title	Year	Author	Number
COMBINED THERAPY BY USING ANTIANGIOGENIC AGENTS AND TNF-ALPHA	2002	Grell' Mattias Gudman Sajmon Rjugg Kurtsio	RU2316337C2
COMBINED THERAPY USING INHIBITORS OF TYROSINE KINASE RECEPTORS AND INHIBITORS OF ANGIOGENESIS	2001	Gudman Sajmon Krejsh Khans-Georg	RU2292904C2
PHARMACEUTICAL COMPOSITIONS AIMED AT Erb-B1 RECEPTORS	2003	Krejsh Khans-Georg Shmidt Jurgen	RU2354402C2
ANGIOPOIETIC ANGIOPOIETIN-LIKE PROTEIN 4 INHIBITORS, IN COMBINATIONS AND APPLICATION	2005	Ferrara Napoleone Gerber Khans-Peter Ljan Sjao Khuan	RU2392966C2
TECHNIQUES AND COMPOSITIONS USED TO INHIBIT αβ-CAUSED ANGIOGENESIS	1997	Bruks Piter Cheresh Dehvid A. Fridlehnder Martin Silletti Stiven	RU2195312C2
YEAST-BASED IMMUNOTHERAPEUTIC COMPOSITIONS WITH BRACHYURY	2012	Schlom, Jeffrey Apelian, David Guo, Zhimin Palena, Claudia	RU2690180C2
ENHANCEMENT OF IMMUNE RESPONSES MEDIATED BY PROTEINS FUSED FROM ANTIBODY AND CYTOKINE BY METHOD OF COMBINED ADMINISTRATION OF ANGIOGENESIS INHIBITOR	1999	Dzhilliz Stefen D.	RU2229305C2
COMBINATION THERAPY FOR TREATING CANCER WITH POXVIRUS EXPRESSING TUMOUR ANTIGEN AND ANTAGONIST AND/OR AGONIST OF IMMUNE CHECKPOINT INHIBITOR	2014	Rauntri, Rajan Foj, Syuzan Mendl, Stefani Delker, Alen	RU2714142C2
IMMUNOTHERAPEUTIC COMPOSITIONS BASED ON YEAST WITH BRACHYURY	2012	Palena Klaudia Go Chzhimin Ejpelian Devid Shlom Dzheffri	RU2619850C2
ANTI-CANCER TARGETED IMMUNOTHERAPY WITH APPLICATION OF IL-12	2015	Shrittmatter Volfgang Khandgretinger Rupert Shilbakh-Shtyukle Karin	RU2689160C2

RU 2 236 251 C2

Authors

Lode Kholger N.

Rehjsfeld Ral'F A.

Cheresh Dehvid A.

Dzhillies Stefen D.

Dates

2004-09-20—Published

2000-02-11—Filed