FIELD: biotechnology.
SUBSTANCE: it is obtained as particles of copolymers of lactic and glycolic acids with antitumour cure of anthracycline series included in them by interaction of -COOH groups of particles activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide with at least 5-fold excess relative to carboxyl groups, with amino groups of the recombinant alpha-fetoprotein having sequences selected from the group: SEQ1, SEQ2, SEQ3, SEQ4, not less than equimolar amounts in relation to activated carboxyl groups, at a pH from 7.4 to 9, followed by purification on a column of Superose 12 carrier with complete separation of reaction products and separation of the desired conjugate in pure form. A method of producing the conjugate is also disclosed.
EFFECT: increase the effectiveness of the antitumour drug.
3 cl, 7 ex, 10 dwg
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