FIELD: medicine, oncology, pharmacy, biochemistry.
SUBSTANCE: invention relates to peptides-containing medicinal preparations. Invention relates to using peptide of the formula QMTOVNOG representing analog of α-fetoprotein fragment from 472-d to 479-th amino acid. This peptide is able for selective trapping by tumor cells and to operate as vector molecule for directed delivery of anti-tumor preparations into tumor cells. Also, invention relates to conjugate of indicated peptide with doxorubicin wherein doxorubicin is added to peptide by through thioester bond covalently. Also, invention relates to a pharmaceutical composition used in treatment of oncology diseases that comprises conjugate of doxorubicin with peptide QMNOVNOG as a vector molecule and taken in the effective dose and a pharmaceutical carrier suitable for intravenous administration. Invention provides the selective effect of conjugate that allows expanding sphere for using the preparation. Invention can be used in medicine in treatment of oncology diseases of different etiology.
EFFECT: valuable medicinal properties of peptide and conjugate.
3 cl, 2 tbl, 6 dwg, 6 ex
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