SUBSTITUTED PHENYL DERIVATIVES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION COMPRISING THEREOF AND METHOD OF TREATMENT (VARIANTS) Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention describes novel substituted phenyl derivatives of the general formula (I) where one of R¹, R², R³ means 4- hydroxy-1,2,4-triazolyl, 3-oxo-1,2- -dihydro-1,2,4-triazolyl, 2-oxo-3H-1,3,4-oxadiazolyl or tetrazolyl; R⁴, R⁵ mean hydrogen atom; two other substitutes R¹, R², R³ where each is taken independently among hydrogen, halogen atom, nitro-, amino-, acylamino-, benzoylamino-group, phenyl, naphthyl, diphenyl or 5- either 6- membered heterocyclic monocyclic group containing one heteroatom taken among atoms N, S and O where phenyl group can be substituted once or more times with substitutes taken among trifluoromethyl, nitro-group, phenyl, carboxy-group, alkoxycarbonyl, aminocarbonyl, dialkylaminocarbonyl and anilinocarbonyl; Y means -CO- of -CS-; X means -NH-; Z means NH; one of R¹¹, R¹², R¹³, R¹⁴, R¹⁵ is taken among hydrogen, halogen atom, trifluoromethyl, -COOR⁷, phenyl or 5- either 6-membered heterocyclic monocyclic group containing from 1 to 3 heteroatoms taken among atoms N, S and O and four other from R¹¹, R¹², R¹³, R¹⁴, R¹⁵ mean hydrogen atom; or one among R¹¹ and R¹²; R¹² and R¹³; R¹³ and R¹⁴; R¹⁴ and R¹⁵ form in common cyclic structure and other substitutes R¹¹, R¹², R¹³, R¹⁴, R¹⁵ mean hydrogen atom; R⁷ means alkyl. Invention relates also to method of their synthesis, pharmaceutical composition and methods of treatment, in part, sickle cell anemia. EFFECT: improved methods of synthesis, preparing and treatment, valuable medicinal properties. 9 cl