FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel derivatives of heteryl-substituted butenoic acid amides eliciting anti-inflammatory activity. Invention describes 4-aryl-2-hydroxy-4-oxo-3-(2-oxo-3,4-dihydro-2H-1,4-benzoxazinyl)-2-butenoic acid triazylamides of the general formula: 
where R = R1 is H (I); R is H, R1 is CH3 (II); R = R1 is CH3 (III); R is H, R1 is OCH3 (IV) eliciting an anti-inflammatory activity. EFFECT: expanded assortment of agents exhibiting useful biological properties. 2 tbl, 2 ex
| Title |
Year |
Author |
Number |
| 2-AROYLMETHYLENE-3,4-DIHYDRO-2H-1,3-BENZOXAZINE-4-ONES ELICITING FLUORESCENT PROPERTY AND METHOD FOR THEIR PREPARING |
2003 |
- Vostrov E.S.
- Maslivets A.N.
- Novikov A.A.
|
RU2240323C1 |
| 5-METHYL-2-OXO-1-PHENYL-4-ETHOXYCARBONYL-2,3-DIHYDRO-1H-PYRROLE-3-SPIRO-2-(3-BENZOYL-4-HYDROXY-1-ORTHO-HYDROXYPHENYL-5-OXO-2,5-DIHYDROPYRROLES) ELICITING ANTIMICROBIAL ACTIVITY WITH RESPECT TO GRAM-POSITIVE MICROFLORA AND METHOD FOR THEIR PREPARING |
2005 |
- Maslivets Andrej Nikolaevich
- Racheva Nadezhda L'Vovna
- Belevich Irina Olegovna
|
RU2294330C1 |
| METHOD FOR PREPARING 1-ALKYL-6,6-DIMETHYL-2,4-DIOXO-2,3,4,5,6,7-HEXAHYDRO-1H-INDOLE-3-SPIRO-2-( 1-ARYL-3-AROYL-4-HYDROXY-5-OXO-2,5-DIHYDROPYRROLS) |
2003 |
- Bannikova Ju.N.
- Maslivets A.N.
|
RU2238272C1 |
| (Z)-4-ARYL-N-[2-(2-HYDROXYMETHYL)PHENYL]-2,4-DIOXO-3-[3-OXO-3,4-DIHYDROQUINOXALINE-2(1N)-YLIDENE]BUTANAMIDES, HAVING ANALGESIC ACTIVITY |
2019 |
- Maslivets Anna Andreevna
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
- Tretyakov Nikita Alekseevich
|
RU2722178C1 |
| 1-AROYLOXY-4-HYDROXY-3-OXO-1,2,3,4,4a,5,6,7,8,8a-DECAHYDROQUINOXALIN-2-SPIRO(1-o-HYDROXYPHENYL-4,5-DIOXO-2,3,4,5-TETRAHYDROPYRROLES) AND METHOD FOR THEIR PREPARING |
2007 |
- Mashevskaja Irina Vladimirovna
- Maslivets Andrej Nikolaevich
- Tikhonov Aleksej Jakovlevich
- Mazhukin Dmitrij Gennad'Evich
|
RU2320660C1 |
| 4-(4-METHYLPHENYL)-4-OXO-2-[3-(ETHOXYCARBONYL-4,5-R,R-THIOPHEN-2-YLAMINO]BUT-2-ENOIC ACID, HAVING ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY |
2008 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgen'Evich
- Makhmudov Ramiz Ragipovich
- Zalesov Vladimir Vasil'Evich
|
RU2389724C1 |
| (Z)-ETHYL2-(4-(4-CHLOROPHENYL)-2,4-DIOXO-3-(3-OXO-3,4-DIHYDROQUINOXALIN-2(1H)-YLIDENE)BUTANAMIDO)-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE HAVING ANTIDIABETIC ACTIVITY, AND METHOD FOR PRODUCTION THEREOF |
2015 |
- Pchelintseva Darya Igorevna
- Kotegov Viktor Petrovich
- Pavlov Petr Timofeevich
- Mashevskaya Irina Vladimirovna
- Makhmudov Ramiz Ragibovich
|
RU2606230C1 |
| INTERMEDIATE PRODUCTS - METHYL 7-ARYL-4, 9-DIAROYL-3-HYDROXY-1-(2-HYDROXYPHENYL)-2,6-DIOXO-1, 7-DIAZASPIRO[4,4]NONE-3, 8-DIENE-8-CARBOXYLATES; METHYL 6, 9-DIARYL-11-AROYL-2-(O-HYDROXYPHENYL)-3, 4,10-TRIOXO-7-OXA-2, 9-DIAZATRICYCLO[6.2.1.0]UNDEC-5-ENE-8-CARBOXYLATES; METHOD OF PRODUCING METHYL 6, 9-DIARYL-11-AROYL-2-(O-HYDROXYPHENYL)-3, 4, 10-TRIOXO-7-OXA-2, 9-DIAZATRICYCLO [6.2.1.0]UNDEC-5-ENE-8-CARBOXYLATES; METHYL 11-BENZOYL-2-O-HYDROXYPHEHYL-3, 4, 10-TRIOXO-9-P-TOLYL-6-PHENYL-7-OXA-2, 9-DIAZATRICYCLO [6.2.1.0]UNDEC-5-ENE-8-CARBOXYLATE HAVING ANTIMICROBIAL ACTIVITY |
2008 |
- Racheva Nadezhda L'Vovna
- Maslivets Andrej Nikolaevich
- Aleksandrova Galina Arsent'Evna
|
RU2383550C1 |
| 6,6-DIMETHYL-8-OXO-5,6,8,9-TETRAHYDROBENZO[F]-PYRROLO[2,1-ALPHA]ISOQUINOLINE-9-SPIRO-2-(3-AROYL-4-HYDROXY-1-O-HYDROXYPHENYL-5-OXO-2,5-DIHYDRO-1H-PYRROLES) AND 6,6-DIMETHYL-8-OXO-5,6,8,9-TETRAHYDROBENZO[F]PYRROLO[2,1-ALPHA]ISOQUINOLINE-9-SPIRO-2-(3-BENZOYL-4-HYDROXY-1-O-HYDROXYPHENYL-5-OXO-2,5-DIHYDRIO-1H-PYRROLE) ELICITING ANALGESIC ACTIVITY AND METHOD FOR THEIR PREPARING |
2006 |
- Anikina Lada Vladimirovna
- Racheva Nadezhda L'Vovna
- Maslivets Andrej Nikolaevich
- Shkljaev Jurij Vladimirovich
|
RU2316557C1 |
| 2-ARYL-2,4-DIHYDROXY-2,5-DIHYDRO-3-HETERYL-5-OXO-1H-PYRROL-1-YL-4-METHYL BENZENESULPHANOLAMIDES WITH ANALGESIC ACTIVITY |
2015 |
- Suchkova Nadezhda Vladimirovna
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
- Mashevskaya Irina Vladimirovna
|
RU2626650C2 |
