METHOD FOR DIAGNOSING THE CASES OF CHRONIC PANCREATITIS Russian patent published in 2003 - IPC

FIELD: medicine. SUBSTANCE: method involves determining cytokines content in blood serum like interleykine 1β (IL 1β), antagonist to interleykine 1β receptors (A/IL 1β), interleykine 8 (IL 8), tumor necrosis factor α (TNF α). IL 1β level growing 7,8- fold under reference value being equal to 20,60±0,87 pg/ml, human A/IL β 5- fold under reference value being equal to 14±0,19 pg/ml, IL 8 growing 3,4- fold under reference value being equal to 19,33±1,39 pg/ml, TNF α level growing 2,6-fold under reference value being equal to 28,70±0,99 pg/ml in male patients; IL β level growing 9,6-fold under reference value being equal to 20,81±0,97 pg/ml, human A/IL β 13-fold under reference value being equal to 13,22±0,15 pg/ml, IL 8 growing 2,3-fold under reference value being equal to 28,88±0,82 pg/ml, TNF α level growing 2,4-fold under reference value being equal to 28,33±1,03 pg/ml in female patients, mild degree of chronic pancreatitis is considered to be the case. IL β level growing 12.5-fold under reference value being equal to 20,62±0,87 pg/ml, human A/IL β 10.4-fold under reference value being equal to 14±0,19 pg/ml, IL 8 growing 3.9-fold under reference value being equal to 19,33±1,39 pg/ml, TNF α level growing 2.6-fold under reference value being equal to 28,70±0,99 pg/ml in male patients; IL β level growing 12.9- fold under reference value being equal to 20,81±0,97 pg/ml, human A/IL β 13-fold under reference value being equal to 13,22±0,15 pg/ml, IL 8 growing 2.7-fold under reference value being equal to 28,88±0,82 pg/ml, TNF α level growing 2,3-fold under reference value being equal to 28,33±1,03 pg/ml in female patients, medium degree of chronic pancreatitis is considered to be the case. IL 1β level growing 14.2-fold under reference value being equal to 20,62±0,87 pg/ml,, human A/IL 1β 15-fold under reference value being equal to 14±0,19 pg/ml,, IL 8 growing 11.8-fold under reference value being equal to 19,33±1,39 pg/ml,, TNF α level growing 3.8- fold under reference value being equal to 28,70±0,99 pg/ml in male patients; IL 1β level growing 13,8-fold under reference value being equal to 13,22±0,15 pg/ml, human A/IL 1β 15-fold under reference value being equal to 20,81±0,97 pg/ml,, IL 8 growing 16.3-fold under reference value being equal to 28,88±0,82 pg/ml, TNF α level growing 3.3-fold under reference value being equal to 28,33±1,03 pg/ml in female patients, severe degree of chronic pancreatitis is considered to be the case. EFFECT: high accuracy of diagnosis; simplified method. 2 tbl