MORPHOLINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2003 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes morpholine derivative of the formula (I) or its pharmaceutically acceptable salt where R¹ is taken among group including: (1) hydrogen atom; (2) C_1-6-alkyl that is unsubtituted or substituted with phenyl or heterocycle where heterocycle is taken among group including imidazolyl or triazolyl and where heterocycle is unsubstituted or substituted with oxo-group; each of R² and R³ means hydrogen atom; R⁶, R⁷, R⁸ are taken independently among group including: (1) hydrogen atom; (2) hydrogen atom, C_1-6-alkyl substituted with halogen atom and (3) halogen atom; R¹¹, R¹², R¹³ are taken independently among hydrogen and halogen atom; X means -O-; Y means -O-; Z represents -alkyl. Novel compounds are antagonists of tachykinin receptors. Invention describes also pharmaceutical composition comprising effective dose of compound by claim 1. EFFECT: valuable medicinal properties of compound. 14 cl