FIELD: organic chemistry, cellular biology. SUBSTANCE: invention relates to group of novel bioconjugative complexes of the general formula a: BAS-L-Bc-L'-(Bc'-L'')n-BAS' where BAS, BAS', BAS'' are bioactive components that can be both similar and different; Bc and Bc' are complexes of phenylboric acid; L, L', L'' are linkers; n = 0 or 1. Invention relates also to three methods of their synthesis, intermediate substances used in their synthesis and representing complexforming reagents and phenylborate cross-linked reagents, method of isolation of required cells population and also to kit or system containing bioconjugate A for isolation of required cells population. EFFECT: improved methods of synthesis and isolation. 9 cl, 26 ex
Title | Year | Author | Number |
---|---|---|---|
2,6-DIHYDROXY-4-AMINOMETHYL BENZOATE DERIVATIVES | 1997 |
|
RU2171250C2 |
COVALENT MODIFICATION OF POLYPEPTIDES WITH POLYETHYLENE GLYCOLS | 1992 |
|
RU2148586C1 |
METHOD OF DETERMINATION OF GLYCOSYLATED HEMOGLOBIN IN THE PRESENCE OF NONGLYCOSYLATED HEMOGLOBIN, ANALYTICAL TEST KIT | 1990 |
|
RU2111494C1 |
INCLUSION COMPLEXES-CONTAINING COMPOSITIONS | 2001 |
|
RU2288921C2 |
FIVE-MEMBERED HETEROCYCLIC PYRIDINE COMPOUNDS AND PREPARATION METHOD AND USE THEREOF | 2014 |
|
RU2668074C2 |
WATER-SOLUBLE HYDROLYTICALLY STABLE ACTIVATED POLYMER, METHOD OF SYNTHESIS OF ACTIVATED POLYETHYLENE GLYCOL (VARIANTS), BIOLOGICALLY ACTIVE CONJUGATE | 1994 |
|
RU2176253C2 |
METHOD FOR FINDING LIGANDS | 2002 |
|
RU2295518C2 |
BETA-CHAIN MIMETICS AND RELATED METHODS | 2003 |
|
RU2333213C2 |
COMPLEX FORMING COMPOUNDS | 2012 |
|
RU2619939C2 |
ANDROSTEN(ANE) (ONE) DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SOLVATE THEREOF, METHODS OF PREPARATION THEREOF, AND METHOD OF MEDICAL TREATMENT | 1994 |
|
RU2144037C1 |
Authors
Dates
2003-04-20—Published
1995-01-27—Filed