BETA-CHAIN MIMETICS AND RELATED METHODS Russian patent published in 2008 - IPC C07D487/04 A61K31/519 

FIELD: chemistry.

SUBSTANCE: invention describes new heterocyclic compounds of the general formula I where A is -(CH)-, -N- or -CH₂-N-; B is -(CH₂)-, -(CH₂-CH₂)-; D is -(CH₂)- or -(C=O)-; W is -(C=O)- or is absent; X is -NH(C=O)- or is absent; Y is oxygen or sulfur; L is hydrogen, -C(O)NHR₃ or -C(=O)OR₄; R₁ is C_1-12alkyl; C_6-10aryl; C_1-6alkoxy; C_6-10aralkyl; C_6-10aralkyloxy; R₂ is saturated or non saturated C_1-10alkyl, possibly substituted; C_1-10alkenyl; C_6-10aralkyloxy; C_1-10alkanedienyl; C_6-10aryl, possibly substituted; C_6-10aralkyl, possibly substituted; benzodioxolyl; piperonyl; chromenonyl; alkyl-C(=O)-; 5-6-membered heteroaryl with one or two nitrogen atoms, or oxygen atom, or sulfur atom, and possibly substituted; R³ is a radical of the formula or benzene; where R^a is C_1-10alkyl, possibly substituted; C_1-10alkenyl; C_3-10cycloalkyl; amino; C_6-10aralkyl; possibly substituted; R^d is hydrogen; C_6-10aralkyl, possibly substituted; R₄ is C_6-10aralkyl; on the condition that if A is -(CH)- then B is -(CH₂)-, D is -(CH₂)-, X is -NH(C=O)- and L is -C(=O)NHR₃; if A is N then B is -(CH₂-CH₂)- and X is absent; if A is -CH₂-N- then B is -(CH₂)-, D is -(CH₂)-, W is -(C=O)-, X is absent and L is hydrogen; the invention also describes a pharmaceutical composition containing the claimed compounds.

EFFECT: obtaining compound with NF-kB transcription inhibition effect, applicable in medicine.

7 cl, 3 tbl, 10 ex, 4 dwg