METHOD FOR DIAGNOSING THE CASES OF BONE METABOLISM DISORDER DISEASES Russian patent published in 2003 - IPC

FIELD: medicine. SUBSTANCE: method involves studying biological fluids for determining concentration of monomeric and homodimeric types of osteoclastogenesis-inhibiting factor (OCIF) in the biological fluid samples by means of monoclonal antibodies equally effective in recognizing both monomer and homodimeric types of OCIF and having dissociation constant less than 10^-9 M with antigen or selectively recognizing dimeric OCIF type and having dissociation constant less than 2•10^-7 M with antigen. A monoclonal antibody is claimed that is capable of equally effectively recognizing both monomer and homodimeric types of OCIF, as well as monoclonal antibody capable of selectively recognizing dimeric OCIF type and a set containing the above mentioned antibodies. EFFECT: high specificity and accuracy of measurements and diagnosis. 15 cl, 6 dwg, 1 tbl