FIELD: chemistry.
SUBSTANCE: invention discloses an antibody or a functional fragment thereof, which specifically identifies a polypeptide coded by a gene in the human body, and inhibits formation of osteoclasts and, optionally, osteoclastic bone resorption. The antibody or functional fragment thereof can be obtained particularly by hybridoma technology using hybridoma #32A1(FERM BP-10999) and #41B1 (FERM BP-11000) disclosed in the invention. Described is a pharmaceutical composition based on the antibody or functional fragment thereof for treating and/or preventing bone pathobolism in a patient, as well as methods of treating and preventing anomalous metabolism of bone tissue using antibodies or functional fragments thereof.
EFFECT: use of the invention enables specific identification gene-expressed human Siglec-15 using the disclosed antibody and inhibit formation of osteoclasts.
39 cl, 80 dwg, 9 tbl, 38 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
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