FIELD: biotechnology, molecular biology, medicine.
SUBSTANCE: invention relates to preparing protein/factor for inhibition of osteoclastogenesis (OCIF) and can be used for treatment and immunological diagnosis of diseases accompanying with bone resorption. Protein OCIF with molecular mass about 60 kDa under reduction conditions with amino acid sequences SEQ ID NO. 1, 2 and 3 is prepared by transformation of host-cell with vector comprising cDNA encoding this protein. Protein OCIF as a component of pharmaceutical composition is used in methods for treatment of osteoporosis, treatment/improvement of bone mass recovery and in method for treatment of injure associated with osseous metabolism. Invention provides preparing a novel protein that inhibits formation of osteoclasts effectively.
EFFECT: improved preparing method, valuable biological and medicinal properties of protein.
12 cl, 15 dwg, 16 tbl, 26 ex
| Title |
Year |
Author |
Number |
| NOVEL PROTEINS AND METHODS OF THEIR PREPARING |
1996 |
- Goto Masaaki
- Tsuda Ehjsuke
- Motizuki Siniti
- Jano Kazuki
- Kobajasi Fumie
- Sima Nobujuki
- Jasuda Khisataka
- Nakagava Nobuaki
- Morinaga Tomonori
- Ueda Masatsugu
- Khigasio Kandzi
|
RU2194714C2 |
| PROTEIN BINDING SPECIFICALLY WITH OSTEOCLASTOGENESIS-INHIBITING FACTOR (OCIF) (VARIANTS), DNA ENCODING ITS (VARIANTS), DNA AS PROBE (VARIANTS), METHOD FOR PREPARING PROTEIN (VARIANTS), METHOD FOR SCREENING SUBSTANCE (VARIANTS), ANTIBODY (VARIANTS), METHOD FOR PREPARING POLYCLONAL ANTIBODY, HYBRIDOMA (VARIANTS), METHOD FOR PREPARING MONOCLONAL ANTIBODY, METHOD FOR ASSAY OF OCIF-BINDING PROTEIN, PHARMACEUTICAL COMPOSITION (VARIANTS) AND MEDICINAL AGENT (VARIANTS) |
1998 |
- Jamaguti Kiodzi
- Jasuda Khisataka
- Nakagava Nobuaki
- Sima Nobujuki
- Kinosaki Masakhiko
- Tsuda Eisuke
- Goto Masaaki
- Jano Kazuki
- Tomojasu Akikhiro
- Kobajasi Fumie
- Vasida Naokhiro
- Takakhasi Ken
- Morinaga Tomonori
- Khigasio Kandzi
|
RU2238949C2 |
| ANTIBODIES RAISED AGAINST PROTEIN RELATED TO HUMAN PARATHYROID HORMONE |
2002 |
- Sato Kokh
- Vakakhara Judzi
- Jabuta Naokhiro
|
RU2322453C2 |
| POLYNUCLEOTIDE ELICITING ABILITY TO ACCELERATE BIOSYNTHESIS OF PRAVASTATIN PRECURSOR ML-236B (VARIANTS), PLASMID EXPRESSION VECTOR, STRAIN PENICILLIUM CITRINUM (VARIANTS), STRAIN ESCHERICHIA COLI (VARIANTS), POLYPEPTIDE ACCELERATING BIOSYNTHESIS OF ML-236B (VARIANTS), PRAVASTATIN PRECURSOR ML-236B, METHOD FOR PREPARING PRAVASTATIN |
2001 |
- Esikava Khirodzi
- Abe Juki
- Ono Tikho
|
RU2236463C2 |
| RECOMBINANT PLASMID DNA P31NC ENCODING 15 AMINO ACID NUCLEOCAPSID PROTEIN OF SWINE REPRODUCTIVE-RESPIRATORY SYNDROME VIRUS AND PROVIDING ITS EXPRESSION IN CELLS OF BACTERIUM ESCHERICHIA COLI |
2001 |
- Andreev V.G.
- Bezborodova S.V.
- Shcherbakov A.V.
- Gusev A.A.
|
RU2205218C2 |
| POLYNUCLEOTIDE SEQUENCE (VARIANTS), POLYPEPTIDE (VARIANTS), FUSED PROTEIN, PHARMACEUTICAL COMPOSITION, MONOCLONAL ANTIBODY, STRAIN OF HYBRID CULTURED CELLS |
1995 |
- Tokhru Takakhasi
- Rjuta Koisi
- Itiro Kavasima
- Nobufuza Serizava
|
RU2143491C1 |
| POLYPEPTIDE THROMBOPOIETIN (TPO), DNA ENCODING POLYPEPTIDE TPO (VERSIONS), METHOD OF PREPARING POLYPEPTIDE (VERSIONS), PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT (VERSIONS), ANTIBODY AGAINST POLYPEPTIDE TPO |
1995 |
- Mijazaki Khirosi
- Kato Takasi
- Okhgami Kin'Ja
- Ivamatsu Akikhiro
- Akakhori Khiromiti
- Kuroki Riota
- Simizu Tosijuki
- Muto Takanori
|
RU2194074C2 |
| PEPTIDE MPI WITHOUT SIGNAL SEQUENCE, DNA ENCODING THEREOF, VECTOR, METHOD FOR ASSAY CAPACITY FOR SECRETION OF TESTING PEPTIDE, METHOD FOR ISOLATING CDNA |
1998 |
- Kitamura Tosio
- Kodzima Tetsuo
|
RU2230751C2 |
| TRANSCRIPTIONAL REGULATORY DNA OF HAMSTER GENE EF-1ALPHA |
1998 |
|
RU2249617C2 |
| RECOMBINANT PLASMID DNA pcL37 ENCODING POLYPEPTIDE WITH PROPERTIES OF HUMAN LIGHT CHAIN OF ANTIBODY AGAINST SMALLPOX VIRUS VACCINE, RECOMBINANT PLASMID DNA pcH37 ENCODING POLYPEPTIDE WITH PROPERTIES OF HEAVY CHAIN OF INDICATED ANTIBODY AND THEIR USING |
2006 |
- Tikunova Nina Viktorovna
- Shingarova Ljudmila Nikolaevna
- Jun Tat'Jana Ehverestovna
- Morozova Vera Vital'Evna
- Aliev Tejmur Kantamirovich
- Boldyreva Elena Filippovna
- Nekrasova Oksana Vasil'Evna
- Polykhalova Ilona Vladimirovna
- Panina Anna Alekseevna
- Kirpichnikov Mikhail Petrovich
- Il'Ichev Aleksandr Alekseevich
- Sandakhchiev Lev Stepanovich
|
RU2317330C2 |
