NEUROPROTECTIVE AGENTS Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, neurology. SUBSTANCE: invention relates to group of compounds of the general formula (I) of high purity degree: where Q represents group of positive charge taken among amido-groups or groups of the formula XYN- where X and Y are similar or different and each can represents hydrogen atom, C₁-C₆-alkyl or a simple group comprising heteroatom, or in common with nitrogen atom to which they are linked form heterocyclic group with nitrogen atom; R^a represents linear or branched alkylene chain or alkylene group comprising from 1 to 6 carbon atoms and each of that is substituted selectively with from 1 to 4 alkyl groups comprising from 1 to 3 carbon atoms; Rb1

R^c both represent alkylene or alkylene group comprising 3 or 4 carbon atoms in linear chain each of that can be substituted selectively with 1 or 2 alkyl groups each of that comprises from 1 to 3 carbon atoms in the total number of carbon atoms 7 in indicated linear chains of R^b and R^c; R² and R³ are similar or differ each of other and each represents hydrogen atom of the formula R, RCO-, ROCO- or RNHCO- where R represents alkyl or aryl group being indicated groups can be substituted selectively with one or more number of substituents α determined below; chiral carbon atom designated by asterisk in -configuration; Z is an amino acid aromatic residue; n = 0 or 1; R¹ represents hydrogen atom or smaller alkyl group that can be substituted selectively with one or more number of substituents α determined below; W represents hydrogen atom or alkyl or aryl group; substituents αz are taken among halogens atoms, amino-groups, alkylamino-groups, dialkylamino- groups, cyano-groups, hydroxyls, alkyl groups (with exception of cases with substitution of alkyl), aryl groups, carbamyl groups, alkyl- and dialkylcarbamyl groups and carboxyl groups and derivatives of latter as esters. Invention relates also to pharmaceutically acceptable salts of compound where the most long chain of compound (except for hydrogen atoms) comprises from 14 to 25 and these compounds elicit neuroprotective effect. Invention relates also to method of treatment of mammals to protect them from neuronal damages. EFFECT: valuable medicinal properties of compounds. 18 cl, 7 tbl, 4 dwg