FIELD: pharmaceuticals.
SUBSTANCE: invention relates to a compound of formula (III), where -R1, -R2, -R3, -R4, -R8, -RA, -Q, -R16, -R17 disclosed in the patent claim, and pharmaceutically acceptable salts thereof, as well as to pharmaceutical compositions, containing compounds of formula (III) for treating a microbial infection.
where -R15: 
.
EFFECT: polymyxin derivatives and use thereof in a combined therapy together with various antibiotics are disclosed.
25 cl, 28 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| POLYMYXIN DERIVATIVES AND USE THEREOF IN A COMBINED THERAPY TOGETHER WITH VARIOUS ANTIBIOTICS | 2014 |
|
RU2730012C2 |
| NITROGEN-CONTAINING TRICYCLIC DERIVATIVES HAVING HIV REPLICATION INHIBITION ACTIVITY | 2016 |
|
RU2720145C2 |
| TRICYCLIC COMPOUNDS AS INHIBITORS OF IMMUNOSUPPRESSION MEDIATED BY TRYPTOPHAN METABOLIZATION | 2014 |
|
RU2667509C2 |
| METHOD FOR PRODUCTION OF HYDROXYLATED CYCLOPENTYL PYRIMIDINE COMPOUNDS | 2013 |
|
RU2643811C2 |
| 2-PHENYLAMINO-3-CYANOPYRAZOLO[1,5-A]PYRIMIDINE, USEFUL AS INHIBITOR OF LEUKOTRIENE A HYDROLASE | 2014 |
|
RU2678196C2 |
| METHOD OF SYNTHESISING E1-ACTIVATING ENZYME INHIBITORS | 2008 |
|
RU2553476C2 |
| QUINOLINES AS FGFR KINASE MODULATORS | 2012 |
|
RU2625303C2 |
| NOVEL ANTICONVULSIVE SUBSTITUTED SULFAMATE DERIVATIVES | 2003 |
|
RU2328502C2 |
| MONOMER DERIVATIVES OF GLYCOPEPTIDE ANTIBIOTIC | 2005 |
|
RU2424248C2 |
| BICYCLIC COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS | 2018 |
|
RU2776846C2 |
