SULFONAMIDE-SUBSTITUTED CHROMANS AND PHARMACEUTICAL COMPOSITION Russian patent published in 2003 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to compounds of the general formula (I): where R₁ and R₂ mean independently each of other hydrogen atom, alkyl with 1, 2, 3, 4, 5 or 6 carbon atoms; R₃ means R₁₀-(C_nH_2n) where R₁₀ is hydrogen atom; n = 0, 1-10; R₄ means R₁₃-C_rH_2r-Z-C_qH_2q; q = 0, 1-8; r = 0, 1-8; Z means CO- NR₁₄, -OCO-NR₁₄, -OC_xH_2x-O-, -OC_xH_2x--CO-O, -CO-O-(C_xH_2x)-O- being addition is possible from both sides; x = 2, 3 or 4; R₁₄ means hydrogen atom, alkyl with 1, 2 or 3 carbon atoms; R₁₃ means hydrogen atom, -NR₁₅R₁₆, C(=NR₁₇NR₁₅-R₁₆, -COOR₁₇, phenyl or N-containing heterocycle with 1-9 carbon atoms being phenyl or N-containing heterocycle are unsubstituted or substituted with a single substitute taken among F, Cl, NO₂, NH₂, OH, aminosulfonyl; R₁₅ and R₁₆ mean independently each of other hydrogen atom or alkyl with 1-4 carbon atoms; or R₁₅ and R₁₆ mean in common chain consisting of 4 or 5 methylene groups one of that -CH₂-group can be replaced for O-, -S-, -NH-, -N(CH₃)- or N(benzyl); R₁₇ means hydrogen atom; R₅, R₆, R₇, R₈ mean independently each of other hydrogen atom, F, Cl, alkyl with 1-5 carbon atoms, -y-C_sH_2sR₁₈ where y means O-; R₁₈ means hydrogen atom, phenyl; s = 0, 1-6; B means hydrogen atom, and their physiologically acceptable salts and pharmaceutical composition that is able to block K(camp)-channel or IKs-channel and containing effective amount of at least one compound of the formula (I) as an active component. Proposed compounds are not toxic practically, exhibit strong and specific blocking effect on K⁺ -channel that is opened by cyclic adenosine monophosphate (cAMP). EFFECT: valuable medicinal and pharmacological properties of compounds. 17 cl, 1 tbl, 62 ex