FIELD: organic chemistry, antibiotics. SUBSTANCE: invention relates to derivative of erythromycin A 9-O- benzodithioloxime of the formula (III) 
where Y1 and Y2 represent hydrogen atoms or trimethylsilyl groups or its crystalline solvate that are used as an intermediate compound for synthesis of clarithromycin. Also, invention proposes methods for preparing clarithromycin of the formula (I) 
on the basis of erythromycin A 9-oxime or its hydrochloride using trimethylsilyl and 1,3-benzodithiol protective groups. EFFECT: increased yield, simplified purification of end product. 8 cl, 7 ex
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