FIELD: pharmacy. SUBSTANCE: invention relates to pharmaceutical composition based on a definite oily phase that comprises a lipophilic pharmaceutically active agent, mixture of diglyceride and monoglyceride taken in the ratio from about 9:1 to about 6:4 (diglyceride : monoglyceride ratio) where diglyceride and monoglyceride are esters of mono- or di-unsaturated fatty acids and glycerol where length chain comprises 16-22 carbon atoms, one or some pharmaceutically acceptable solvents and one or some pharmaceutically acceptable surface-active substances. This composition is prepared in the form of self- emulsifying composition that provides high concentration and high oral availability for pyranone lipophilic compounds. EFFECT: valuable pharmaceutical properties of composition. 31 cl, 3 tbl, 53 ex
