PHARMACEUTICAL EMULSION CONTAINING BIOLOGICALLY ACTIVE STEROIDS AND METHOD OF EMULSION PREPARING Russian patent published in 1999 - IPC

Abstract RU 2141313 C1

FIELD: medicine, pharmacy. SUBSTANCE: invention relates to new emulsions of type "oil-in-water" that can be used for parenteral administration into the body biologically active steroids exhibiting the limited solubility in usual solvents. Lipid phase of an emulsion has castor oil and phospholipid emulsifier made of an egg yolk. The content of components per 1 ml of an emulsion is the following: steroid from 0.1 to 15 mg, castor oil from 50 to 200 mg and an emulsifier - an egg yolk phospholipids from 5 to 50 mg. For emulsion preparing steroids are dissolved in lipid phase and the formed steroid-lipid phase is emulsified in an aqueous phase containing water and an egg yolk phospholipids. The novel emulsion has significant amounts of steroids dissolved in lipid phase in combination with increased physical and chemical stability that results to decrease of the total lipid loading and amounts of solubilizing and stabilizing agents administrated in the patient organism. EFFECT: improved quality and properties of an emulsion. 8 cl, 5 ex

Similar patents RU2141313C1

Title Year Author Number
PHARMACEUTICAL SELF-EMULSIFYING COMPOSITION AND ITS CARRIER FOR LIPOPHILIC PHARMACEUTICALLY ACTIVE AGENTS 1998
  • Morozovich Uolter
  • Gao Ping
RU2211021C2
PHARMACEUTICAL COMPOSITION FOR ACID LIPOPHILIC COMPOUNDS IN FORM OF SELF-EMULSIFYING COMPOSITION 1998
  • Morozovich Uolter
  • Gao Ping
RU2202346C2
SELF-EMULSIFYING COMPOSITION FOR LIPOPHILIC COMPOUNDS 1998
  • Morozovich Uolter
  • Gao Ping
RU2203648C2
LIPID-CONTAINING PHARMACEUTICAL COMPOSITION 1993
  • Khokan Njukvist
  • Monika Ehjnarsson
  • Krister Mattsson
RU2128505C1
INHALATION FATTY EMULSION 1999
  • Sonoke Satoru
  • Seki Dzunzo
RU2212230C2
DISPERSIBLE PHARMACEUTICAL COMPOSITIONS 2003
  • Britten Nehnsi Dzh.
  • Uoldron Niki A.
  • Berns Dzhon U.
RU2311201C2
EMULSION OF TYPE "OIL-IN-WATER", CARRIER ON ITS BASE AND PHARMACEUTICAL COMPOSITION 1995
  • Andres Karl'Sson
  • Marina Delogu
  • Bengt Kherslef
RU2131266C1
STRUCTURED LOW TOXIC EMULSION OF AMPHOTHERICIN B FOR PARANTHERAL ADMINISTRATION AND METHOD FOR PRODUCTION THEREOF 2001
  • Pai Srikantkh Annappa
  • Rivankar Sangeeta Khanurmesh
  • Kocharekar Shilpa Sudkhakar
RU2275899C2
PROPOFOL STABLE CLEAR COMPOSITIONS 2001
  • Pai Srikantkh Annappa
  • Rivankar Sangeeta Khanurmesh
  • Kocharekar Shilpa Sudkhakar
RU2257892C2
THERAPEUTIC APPLICATION OF KRILL OIL 2012
  • Driskoll Devid F.
RU2625760C2

RU 2 141 313 C1

Authors

Khall'Grimur Jonasson

Pujong Li

Tomas Stenstrem

Kennet Rosenkvist

Ann Maliniak

Dates

1999-11-20Published

1994-07-01Filed