FIELD: pharmaceutical industry and infection diseases.
SUBSTANCE: invention relates to pharmaceutical compositions for treatment and prevention of bacterial infections. Pharmaceutical composition comprises filler containing (a) amphipathic oil, which is dispersible in water and insoluble in ethanol, (b) microcrystalline wax, (c) pharmaceutically acceptable non-aqueous carrier, and further contains antibacterial agent stably dispersed in filler in antibacterial efficient amount. Composition is suitable to be introduced by means of intramammar infusion to a milk-producing animal for treatment or prevention of mastitis or another udder disease, or for to be aurally introduced for treatment and/or prevention of infectional year disease. Industrially-made article comprises container or delivering device having oxygen-permeable wall or accommodating indicated composition. Method of treatment or prevention of bacterial disease in a subject comprises introducing indicated composition into liquid-containing subject's organ through natural outside opening of this organ, composition being dispersed in mentioned liquid during the introduction.
EFFECT: lowered interphase tension in composition, which allows antibacterial agent contained in composition to be quickly dispersed resulting in a rapid achievement of effective levels of drug on infection-damaged site.
18 cl, 7 ex
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Authors
Dates
2007-11-27—Published
2003-12-11—Filed