FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel pyrimido[4,5-b]indoles of the general formula (I) or their pharmaceutically acceptable salts that can be used in treatment and/or prophylaxis of asthma and to intermediate compounds used for their synthesis. Indicated compounds are nontoxic substances. In pyrimido[4,5-b]indoles of the general formula (I) R1-1 and R1-2 in common with nitrogen atom bound with its form 1-pyrrolidinyl; R2-1 and R2-2 in common with nitrogen atom bound with its form 1-pyrrolidinyl; n means a number from 1 to 3; R3-1 means H and R3-2 means (1) H; (2) CH2-(2-pyridyl); (3) CH2-(3-pyridyl); (4) CH2-(4-pyridyl); (5) -(CH2)-[CH(OH)]4-CH2OH; (6) CH2CH2CH2CH2OH; or R3-1 and R3-2 in common with nitrogen atom bound with its form heterocyclic ring taken among (1)1-pyrrolidinyl, (2)1-piperidinyl, (3)4-morpholinyl, (4)2-hydroxy-1-pyrrolidinyl, (5)3-hydroxy-1-pyrrolidinyl, (6)1-prolinyl. EFFECT: valuable medicinal properties of compounds. 11 cl, 3 tbl
Authors
Dates
2003-03-20—Published
1997-12-19—Filed