TRICYCLIC COMPOUNDS, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION AND TREATMENT METHOD Russian patent published in 2003 - IPC

FIELD: organic chemistry, chemical technology, medicine, endocrinology, pharmacy. SUBSTANCE: invention describes novel tricyclic compounds of the general formula (I) wherein: A and B mean independently CH or nitrogen atom; D means C-W or nitrogen atom; W means hydrogen, halogen atom, C_1-6-alkyl or group CH₂NR⁶R⁷ wherein R⁶ and R⁷ mean independently C_1-6- alkyl with direct chain; E and G mean CH or nitrogen atom simultaneously; R¹ means alkanoyl with 2-7 carbon atoms, group taken among CN, CONH₂ or residue taken among the following groups: (A) , (b) , (c) , (d) , (e) , (f) , (g) , (h) , (i) , (j) , (k) and (m) wherein R² is hydrogen atom or C_1-6- alkyl with direct chain, C_3-7-cycloalkyl or CF₃; R³ and R⁵ mean independently hydrogen atom or C_1-6- alkyl; R⁴ is hydrogen atom, C_1-6-alkyl with direct chain, alkoxyalkyl with 2-7 carbon atoms, cycloalkanoyl with 3-7 carbon atoms, benzoyl substituted with halogen atom, C_1-6/ -alkyl or phenyl that in turn can be unsubstituted or substituted with CF₃, or thiophenealkanoyl; X is hydrogen atom; Y is hydrogen atom, C_1-6- alkyl with direct chain, C_1-6-alkoxy, hydroxy, halogen atom or CF₃, or their pharmaceutically acceptable salts. Invention relates also to methods for their preparing, pharmaceutical composition eliciting activity of vasopressin agonist and method for treatment of disease or state of mammal, in part, diabetes insipidus wherein activity of vasopressin agonist is desirable. EFFECT: improved preparing method, valuable medicinal properties of compounds and composition. 23 cl, 1 tbl 123 ex