RAPAMYCIN 42-OXIMES AND HYDROXYLAMINES, METHOD OF SYNTHESIS, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT OF PATIENT Russian patent published in 2001 - IPC

FIELD: organic chemistry, antibiotics, pharmacy. SUBSTANCE: invention describes novel compounds of the formula (I) where X-Y is C=NO-R¹ or CHNHO-R² where R¹ means hydrogen atom, alkyl with 1-6 carbon atoms, alkenyl with 2-7 carbon atoms, alkynyl with 2-7 carbon atoms, group of the formula (CH₂)-mAr where Ar means phenyl or pyridinyl and m = 1-6; R² means hydrogen atom or radical of the formula (CH₂)-mAr where Ar means pyridinyl, or their pharmaceutically acceptable salts. Invention describes also method of their synthesis, intermediate compound, pharmaceutical composition and method of treatment of patients. New compounds are useful as immuno-depressants, anti-inflammatory, antifungal, antiproliferative and antitumor agents. EFFECT: new compounds indicated above, improved method of synthesis, valuable medicinal properties. 18 cl