INHIBITORS OF ENZYMES CONVERTING 1β-INTERLEUKIN Russian patent published in 2003 - IPC

FIELD: organic chemistry, biochemistry, medicine. SUBSTANCE: invention relates to compounds of the general formulas α- and β-: and , wherein n = 0, 1 or 2; m and m' represent 1 or 2; R¹¹ means: or ; R^2′ = R² is hydrogen atom; R³ is -CH₂Ar or 5-15-membered nonaromatic monocyclic group that can comprise from 0 to 2 endocyclic nitrogen atoms; R₄ is unbranched (C_1-5)-alkyl group; R⁵ is taken among group including -C(0)R⁷, -C(0)OR₉, -C(0)C(0)R₇; R₇ is taken among the group: phenyl, naphthyl, isoquinoline being phenyl can be substituted with halogen atom, (C_1-6)-alkoxy group, 1,2-methylenedioxy-group or N(H)C(O)-(C_1-6)-alkyl; R₉ is taken independently among direct -alkyl group optionally substituted with phenyl; R₁₂ and R₁₃ are taken independently among the group including R₇, -C(O)-R₇ and C(O)-N(H)-R₇; or R₁₂ and R₁₃ form in common 4-8-membered saturated cyclic group. Invention relates to pharmaceutical composition used for inhibition of activity of enzyme converting 1β-interleukin (ICE), to method for inhibition of activity of ICE, to methods for treatment or prophylaxis of IL-mediated diseases. EFFECT: valuable medicinal properties of compounds. 14 cl, 1 tbl