INDENE DERIVATIVES AS PHARMACEUTICAL AGENTS Russian patent published in 2010 - IPC C07C35/21 C07C35/32 C07C35/52 C07C215/42 C07C233/18 C07C279/02 C07C311/04 C07D213/24 C07D207/06 C07D233/56 C07D265/30 A61K31/47 A61K31/133 A61K31/155 A61K31/164 A61K31/18 A61K31/4164 A61K31/401 A61K31/44 A61K31/5375 A61P29/00 

Abstract RU 2381209 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I) in form of a separate stereoisomer, a mixture of stereoisomers or a racemic mixture of stereoisomers and their pharmaceutically acceptable salts. In formula (I) ring A, C or D is independently completely or partially saturated; each of C1, C4, C11, C12, C15 and C16 is independently substituted with two hydrogen atoms; each of C9 and C14 is independently substituted with a hydrogen atom; R1 represents -OR7 or -N(R7)2. Values of the rest of the radicals are given in the formula of invention. The invention also relates to a pharmaceutical composition with anti-inflammatory activity and contains an effective amount of the disclosed compound and to use of the said compounds to make a medicinal agent with anti-inflammatory activity.

EFFECT: disclosed compounds have anti-inflammatory activity.

23 cl, 47 ex

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Authors

Rajmond Dzheffri R.

Khan' Kan

Chzhou Juan'Lin'

Kheh Juehkhua

Noren Brehdli

Ji Dzhejms Dzhi Ken

Dates

2010-02-10Published

2004-04-15Filed