METHOD FOR PREPARING PACLITAXEL AND INTERMEDIATE COMPOUNDS FOR ITS PARTIAL SYNTHESIS Russian patent published in 2003 - IPC

FIELD: organic chemistry, chemical technology, medicine, oncology. SUBSTANCE: invention relates to a novel method for preparing paclitaxel an antitumor agent and intermediate compounds for its partial synthesis, namely to compound of the formula (II) wherein A represents group: ; R₁ is a group for protection of hydroxyl or hydrogen atom; R₂ is hydrogen atom and to compound of the formula (III): wherein each group R₄ and R₅ means aryl and each group R₆ and R₇ means halogenated methyl. Invention provides preparing paclitaxel and its analogues using new intermediate compounds. EFFECT: improved preparing method. 10 cl, 1 tbl, 8 ex