CYTOMODULATING LIPOPHILIC PEPTIDES FOR MODULATION OF IMMUNE SYSTEM ACTIVITY AND SUPPRESSION OF INFLAMMATION Russian patent published in 2003 - IPC

FIELD: biologically active peptides. SUBSTANCE: invention relates to oligopeptides comprising amino acid sequence B-X-X-X-B-X-X-X-J-Tyr, in which: B represents Lys or Arg; X represents any amino acid other than a charged aliphatic amino acid or its D-isomer; and J represents Gly, Lys, or Arg; indicated amino acids being naturally occurring L isomers, their D-isomers, and norleucine, whereas indicated oligopeptide includes active part, which is other than (i) naturally occurring sequence of alpha-domain of antigen B of human leukocyte (HLA-B) 75-84, (ii) naturally occurring sequence of transmembrane sequence of alpha-chain of human T cell receptor, and (iii) sequence, which is mutant with respect either to (i) or to (ii) and has no more than two mutations. Invention also discloses: method of suppressing activation of lymphocyte cells, method of transplantation of animal donor organs or cells, method of inhibiting inflammatory citokin protein synthesis in cells, method of suppressing inflammatory reaction in mammals, method of modulating activity of hemecontaining enzyme, and method of retarding appearance of autoimmune disease in mammals. EFFECT: expanded possibilities of suppressing inflammatory diseases. 36 cl, 2 dwg, 2 tbl, 9 ex _