FIELD: molecular biology, medicine. SUBSTANCE: invention relates to hybrid protein containing (I) the known protein that binds with mastocytes and/or basophiles by the known manner or absorbs by such manner, and (II) protease that cleaves one or more protein in apparatus of secretion of mastocytes and/or basophiles or consisting of them. Hybrid protein shows high inhibitory activity with respect to granulation of mastocytes. EFFECT: valuable properties of hybrid protein. 5 cl, 9 ex
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