FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to substituted derivatives of benzo(b)thiepine-1,1-oxides and their additive salts with acids of the formula (I) 
wherein R1 is methyl, ethyl, propyl, butyl; R2 is hydrogen atom, hydroxyl; R3 is a residue of amino acid, diamino acid being residue of amino acid, residue of diamino acid are mono- or multiple substituted, if necessary, with amino-protective group; R4 is methyl, ethyl, propyl, butyl; R5 is methyl, ethyl, propyl, butyl; Z is covalent bond. Invention describes also method for preparing compounds, medicine based on thereof and method for preparing medicine. Compounds can be used as hypolipidemic agents. EFFECT: improved preparing method, valuable medicinal properties of compounds. 6 cl, 1 tbl, 4 ex
| Title |
Year |
Author |
Number |
| COMBINED PREPARATIONS FROM 1,4-BENZOTHIEPINE-1,1-DIOXIDE DERIVATIVES WITH OTHER BIOLOGICALLY ACTIVE SUBSTANCES AND USES THEREOF |
2002 |
- Glombik Khajner
- Frik Vendelin
- Shefer Khans-Ljudvig
- Kramer Verner
|
RU2297222C2 |
| DERIVATIVES OF BENZOTHIEPINE-1,1-DIOXIDES, METHOD FOR THEIR PREPARING AND MEDICINAL AGENT |
1999 |
- Frik Vendelin
- Ehnzen Al'Fons
- Glombik Khajner
- Khojer Khubert
|
RU2220141C2 |
| DERIVATIVES OF 1,4-BENZOTHIAZEPINE-1,1-DIOXIDE SUBSTITUTED WITH SUGAR RESIDUES, METHOD FOR THEIR PREPARING, MEDICINAL AGENT BASED ON THEREOF AND METHOD FOR ITS PREPARING |
2000 |
- Frik Vendelin
- Glombik Khajner
- Khojer Khubert
- Shefer Khans-Ljudvig
|
RU2232155C2 |
| DERIVATIVES OF 1,3-DIARYL-2-PYRIDINE-2-YL-3-(PYRIDINE-2-YLAMINO)PROPANOL AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1999 |
- Kirsh Rajnkhard
- Ehnsen Al'Fons
- Glombik Khajner
- Kramer Verner
- Fal'K Ojgen
|
RU2224748C2 |
| POLYCYCLIC THIAZOLIDINE-2-YLIDENE AMINES, MEDICINAL AGENTS CONTAINING THEREOF AND METHOD FOR PREPARING MEDICINAL AGENT |
1999 |
- Jene Gerkhard
- Gajzen Karl
- Lang Khans Jokhen
|
RU2236405C2 |
| SULFONYLAMINOCARBOXYLIC ACIDS |
1998 |
- Torvart Verner
- Shvab Vil'Frid
- Shudok Manfred
- Khaaze Burkkhard
|
RU2193027C2 |
| DERIVATIVES OF PHOSPHINIC AND PHOSPHONIC ACIDS, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1999 |
- Shudok Manfred
- Shvab Vil'Frid
- Tsoller Gerkhard
- Bartnik Ehkkart
- Bjuttner Frank
- Vajtmann Klaus-Ul'Rikh
|
RU2224762C2 |
| NEW FIVE-MEMBER HETEROCYCLES, THEIR PREPARING, THEIR APPLYING AND PHARMACEUTICAL PREPARATIONS COMPRISING THEREOF |
1998 |
- Vener Fol'Kmar
- Shtil'Ts Khans Ul'Rikh
- Shmidt Vol'Fgang
- Zajffge Dirk
|
RU2240326C2 |
| DERIVATIVES OF ISOXAZOLE AND CROTONIC ACID AMIDE |
1998 |
- Mjullner Shtefan
- Kirshbaum Bernd
- Shvab Vilfrid
|
RU2192421C2 |
| AROMATIC DIKETONE DERIVATIVES, METHODS FOR PRODUCTION THEREOF AND USES AS PHARMACEUTICALS |
2000 |
- Verteshi Laslo
- Kurts Mikhel'
- Paulus Ehrikh
|
RU2252211C2 |
