GRANULES WITH POLYETHYLENE GLYCOL MATRIX FOR FAT, OILY OR GLUE MEDICINAL SUBSTANCES Russian patent published in 2003 - IPC

FIELD: medicine, pharmacy. SUBSTANCE: invention relates to dry, solid oral composition for delivery of drug that is made as multiple of granules. Granules comprise polymeric matrix where from 15 to 70 wt.-% of fat, oily or glue substance are included in combination with pharmaceutically active substance or indicated amount of pharmaceutically active substance that shows fat, oily or glue properties. Polymeric matrix consists of polyethylene glycol or mixture of polyethylene glycols that are solid at environment temperature. Pharmaceutically active substance is peptide drug inhibiting thrombin, dihydropyridine drug or alendronate. Composition elicits properties of rapid release that provides simultaneous delivery of drug and absorption enhancer or solubility enhancer to required site in the high concentration. High gradient of concentration enhances possibility for drug absorption. EFFECT: improved and valuable properties of granules. 11 cl, 5 ex